The Top 50 Peptides

The most popular, most discussed, and most used peptides — ranked

Educational and informational only — not medical advice. Legal status varies by compound and country; many entries are research-use-only or investigational.

How we rank

The Peptide Popularity Score

A composite "Peptide Popularity Score" blending real-world demand, community discussion, clinical and real-world use, depth of research, and momentum. It ranks how prominent a peptide is right now — not how effective or safe it is.

30%
Demand
20%
Discussion
20%
Real-world use
20%
Research
10%
Momentum

Every entry links to its full page in the Peptide Database — mechanism, uses, dosing ranges, legal status, and verified sources. Inclusion is not medical advice or an endorsement; many of these are research chemicals sold for laboratory use only.

1SemaglutideWeight Loss98
FDA-approved

The GLP-1 that curbs appetite and drives major weight loss — the drug behind Ozempic and Wegovy.

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2TirzepatideWeight Loss96
FDA-approved

Dual GIP/GLP-1 agonist for weight loss and diabetes — the drug behind Mounjaro and Zepbound.

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3BPC-157Recovery93
Research chemical

The go-to healing peptide — speeds repair of muscle, tendon, ligament, and gut.

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4RetatrutideWeight Loss88
Investigational

Triple-agonist in trials posting the biggest weight-loss numbers yet.

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5TB-500Recovery85
Research chemical

Systemic healing peptide that promotes tissue repair throughout the body.

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6MK-677Growth Hormone84
Research chemical

Oral compound that raises your own growth hormone and IGF-1 — no injections.

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7Melanotan IISexual Health82
Research chemical

Darkens skin for tanning and boosts libido.

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8CJC-1295Growth Hormone80
Research chemical

Long-acting GHRH that raises growth-hormone output, usually stacked with ipamorelin.

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9IpamorelinGrowth Hormone79
Research chemical

Gentle, selective growth-hormone releaser with minimal side effects.

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10GHK-CuLongevity77
Cosmetic / research

Copper peptide for skin repair, collagen, and hair — a skincare and healing staple.

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11GlutathioneLongevity76
Supplement / OTC

The body's master antioxidant — a mainstay of IV drips and longevity clinics.

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12PT-141Sexual Health75
FDA-approved

Melanocortin peptide (Bremelanotide) that boosts sexual arousal in men and women.

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13SemaxNootropic73
Research chemical

Russian nootropic peptide for focus, memory, and neuroprotection.

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14SelankNootropic72
Research chemical

Calming nootropic peptide for anxiety and stress without sedation.

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15MOTS-cLongevity71
Research chemical

Mitochondrial peptide that acts like exercise on your metabolism.

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16GonadorelinSexual Health70
Prescription

GnRH peptide used with TRT to keep natural testosterone and fertility online.

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17SermorelinGrowth Hormone69
Prescription

GHRH peptide that nudges the body to make more of its own growth hormone.

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18TesamorelinGrowth Hormone68
FDA-approved

FDA-approved GHRH that targets visceral belly fat.

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195-Amino-1MQWeight Loss67
Research chemical

NNMT-blocking compound studied for burning fat and raising NAD+.

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20CagrilintideWeight Loss66
Investigational

Long-acting amylin analog paired with semaglutide (CagriSema) for weight loss.

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21EpithalonLongevity65
Research chemical

Telomere and longevity peptide studied for healthy aging and sleep.

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22Thymosin Alpha-1Immune64
Approved abroad

Immune-boosting peptide used to strengthen and balance immune defense.

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23GHRP-2Growth Hormone62
Research chemical

Growth-hormone releasing peptide that also raises appetite.

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24OxytocinSexual Health61
Prescription

The bonding hormone — used off-label for connection, mood, and intimacy.

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25AOD-9604Weight Loss60
Research chemical

Fragment of growth hormone studied for fat loss without GH's other effects.

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26BPC-157 + TB-500 BlendRecovery59
Research chemical

Popular healing stack combining local and systemic tissue repair.

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27Melanotan ICosmetic58
Prescription (approved form)

Tanning peptide focused on pigmentation; its implant form is approved for a light-sensitivity disorder.

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28ArgirelineCosmetic57
Cosmetic / OTC

Topical 'Botox in a jar' peptide that softens expression lines.

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29Kisspeptin-10Sexual Health55
Research chemical

Hormone-signaling peptide studied for reproductive health and libido.

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30IGF-1 LR3Recovery54
Research chemical

Long-acting growth factor used for muscle growth and recovery.

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31Follistatin-344Recovery53
Research chemical

Myostatin blocker studied for major muscle growth.

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32MGFRecovery52
Research chemical

IGF-1 splice variant that helps kick off muscle repair after training.

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33GHRP-6Growth Hormone51
Research chemical

Early growth-hormone releaser that strongly stimulates hunger.

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34HexarelinGrowth Hormone50
Research chemical

Potent growth-hormone releaser, the strongest of the GHRP family.

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35DSIPNootropic49
Research chemical

Sleep-associated neuropeptide used for rest and stress resilience.

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36CerebrolysinNootropic48
Approved abroad

Neurotrophic peptide mix used abroad for stroke, dementia, and brain recovery.

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37SurvodutideWeight Loss47
Investigational

GLP-1/glucagon dual agonist in trials for obesity and fatty-liver disease.

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38MazdutideWeight Loss46
Investigational

GLP-1/glucagon dual agonist advancing fast for obesity, especially in China.

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39HumaninLongevity45
Research chemical

Mitochondrial peptide studied for neuroprotection and longevity.

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40KPVImmune44
Research chemical

Small anti-inflammatory peptide for gut and skin inflammation.

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41LarazotideImmune43
Research chemical

Gut tight-junction regulator studied for leaky gut and celiac disease.

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42MatrixylCosmetic42
Cosmetic / OTC

Collagen-boosting peptide in many premium anti-aging skincare products.

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43LL-37Immune41
Research chemical

Antimicrobial peptide studied for infection, biofilms, and wound healing.

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44FOXO4-DRILongevity40
Experimental

Experimental senolytic that clears aged 'zombie' cells.

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45SS-31Cardiovascular39
Research chemical

Mitochondria-targeting peptide protecting heart, muscle, and kidney energy.

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46DihexaNootropic38
Research chemical

Powerful nootropic peptide studied for memory and new synapse formation.

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47ThymalinImmune37
Research chemical

Thymus peptide bioregulator studied for immune restoration in aging.

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48VIPImmune36
Research chemical

Signaling peptide used (often intranasally) for chronic inflammation and CIRS.

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49PinealonLongevity35
Research chemical

Brain-targeting peptide bioregulator studied for neuroprotection.

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50SNAP-8Cosmetic34
Cosmetic / OTC

Topical peptide marketed as a needle-free alternative to Botox.

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Looking for a verified source?

Every peptide above links to its full research page and vetted suppliers. Browse the full Peptide Database, or list your brand.

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