The Top 50 Peptides
The most popular, most discussed, and most used peptides — ranked
Educational and informational only — not medical advice. Legal status varies by compound and country; many entries are research-use-only or investigational.
The Peptide Popularity Score
A composite "Peptide Popularity Score" blending real-world demand, community discussion, clinical and real-world use, depth of research, and momentum. It ranks how prominent a peptide is right now — not how effective or safe it is.
Every entry links to its full page in the Peptide Database — mechanism, uses, dosing ranges, legal status, and verified sources. Inclusion is not medical advice or an endorsement; many of these are research chemicals sold for laboratory use only.
1SemaglutideWeight LossFDA-approved98▸
The GLP-1 that curbs appetite and drives major weight loss — the drug behind Ozempic and Wegovy.
View in the Peptide Database — research, dosing & verified sources →2TirzepatideWeight LossFDA-approved96▸
Dual GIP/GLP-1 agonist for weight loss and diabetes — the drug behind Mounjaro and Zepbound.
View in the Peptide Database — research, dosing & verified sources →3BPC-157RecoveryResearch chemical93▸
The go-to healing peptide — speeds repair of muscle, tendon, ligament, and gut.
View in the Peptide Database — research, dosing & verified sources →4RetatrutideWeight LossInvestigational88▸
Triple-agonist in trials posting the biggest weight-loss numbers yet.
View in the Peptide Database — research, dosing & verified sources →5TB-500RecoveryResearch chemical85▸
Systemic healing peptide that promotes tissue repair throughout the body.
View in the Peptide Database — research, dosing & verified sources →6MK-677Growth HormoneResearch chemical84▸
Oral compound that raises your own growth hormone and IGF-1 — no injections.
View in the Peptide Database — research, dosing & verified sources →7Melanotan IISexual HealthResearch chemical82▸
Darkens skin for tanning and boosts libido.
View in the Peptide Database — research, dosing & verified sources →8CJC-1295Growth HormoneResearch chemical80▸
Long-acting GHRH that raises growth-hormone output, usually stacked with ipamorelin.
View in the Peptide Database — research, dosing & verified sources →9IpamorelinGrowth HormoneResearch chemical79▸
Gentle, selective growth-hormone releaser with minimal side effects.
View in the Peptide Database — research, dosing & verified sources →10GHK-CuLongevityCosmetic / research77▸
Copper peptide for skin repair, collagen, and hair — a skincare and healing staple.
View in the Peptide Database — research, dosing & verified sources →11GlutathioneLongevitySupplement / OTC76▸
The body's master antioxidant — a mainstay of IV drips and longevity clinics.
View in the Peptide Database — research, dosing & verified sources →12PT-141Sexual HealthFDA-approved75▸
Melanocortin peptide (Bremelanotide) that boosts sexual arousal in men and women.
View in the Peptide Database — research, dosing & verified sources →13SemaxNootropicResearch chemical73▸
Russian nootropic peptide for focus, memory, and neuroprotection.
View in the Peptide Database — research, dosing & verified sources →14SelankNootropicResearch chemical72▸
Calming nootropic peptide for anxiety and stress without sedation.
View in the Peptide Database — research, dosing & verified sources →15MOTS-cLongevityResearch chemical71▸
Mitochondrial peptide that acts like exercise on your metabolism.
View in the Peptide Database — research, dosing & verified sources →16GonadorelinSexual HealthPrescription70▸
GnRH peptide used with TRT to keep natural testosterone and fertility online.
View in the Peptide Database — research, dosing & verified sources →17SermorelinGrowth HormonePrescription69▸
GHRH peptide that nudges the body to make more of its own growth hormone.
View in the Peptide Database — research, dosing & verified sources →18TesamorelinGrowth HormoneFDA-approved68▸
FDA-approved GHRH that targets visceral belly fat.
View in the Peptide Database — research, dosing & verified sources →195-Amino-1MQWeight LossResearch chemical67▸
NNMT-blocking compound studied for burning fat and raising NAD+.
View in the Peptide Database — research, dosing & verified sources →20CagrilintideWeight LossInvestigational66▸
Long-acting amylin analog paired with semaglutide (CagriSema) for weight loss.
View in the Peptide Database — research, dosing & verified sources →21EpithalonLongevityResearch chemical65▸
Telomere and longevity peptide studied for healthy aging and sleep.
View in the Peptide Database — research, dosing & verified sources →22Thymosin Alpha-1ImmuneApproved abroad64▸
Immune-boosting peptide used to strengthen and balance immune defense.
View in the Peptide Database — research, dosing & verified sources →23GHRP-2Growth HormoneResearch chemical62▸
Growth-hormone releasing peptide that also raises appetite.
View in the Peptide Database — research, dosing & verified sources →24OxytocinSexual HealthPrescription61▸
The bonding hormone — used off-label for connection, mood, and intimacy.
View in the Peptide Database — research, dosing & verified sources →25AOD-9604Weight LossResearch chemical60▸
Fragment of growth hormone studied for fat loss without GH's other effects.
View in the Peptide Database — research, dosing & verified sources →26BPC-157 + TB-500 BlendRecoveryResearch chemical59▸
Popular healing stack combining local and systemic tissue repair.
View in the Peptide Database — research, dosing & verified sources →27Melanotan ICosmeticPrescription (approved form)58▸
Tanning peptide focused on pigmentation; its implant form is approved for a light-sensitivity disorder.
View in the Peptide Database — research, dosing & verified sources →28ArgirelineCosmeticCosmetic / OTC57▸
Topical 'Botox in a jar' peptide that softens expression lines.
View in the Peptide Database — research, dosing & verified sources →29Kisspeptin-10Sexual HealthResearch chemical55▸
Hormone-signaling peptide studied for reproductive health and libido.
View in the Peptide Database — research, dosing & verified sources →30IGF-1 LR3RecoveryResearch chemical54▸
Long-acting growth factor used for muscle growth and recovery.
View in the Peptide Database — research, dosing & verified sources →31Follistatin-344RecoveryResearch chemical53▸
Myostatin blocker studied for major muscle growth.
View in the Peptide Database — research, dosing & verified sources →32MGFRecoveryResearch chemical52▸
IGF-1 splice variant that helps kick off muscle repair after training.
View in the Peptide Database — research, dosing & verified sources →33GHRP-6Growth HormoneResearch chemical51▸
Early growth-hormone releaser that strongly stimulates hunger.
View in the Peptide Database — research, dosing & verified sources →34HexarelinGrowth HormoneResearch chemical50▸
Potent growth-hormone releaser, the strongest of the GHRP family.
View in the Peptide Database — research, dosing & verified sources →35DSIPNootropicResearch chemical49▸
Sleep-associated neuropeptide used for rest and stress resilience.
View in the Peptide Database — research, dosing & verified sources →36CerebrolysinNootropicApproved abroad48▸
Neurotrophic peptide mix used abroad for stroke, dementia, and brain recovery.
View in the Peptide Database — research, dosing & verified sources →37SurvodutideWeight LossInvestigational47▸
GLP-1/glucagon dual agonist in trials for obesity and fatty-liver disease.
View in the Peptide Database — research, dosing & verified sources →38MazdutideWeight LossInvestigational46▸
GLP-1/glucagon dual agonist advancing fast for obesity, especially in China.
View in the Peptide Database — research, dosing & verified sources →39HumaninLongevityResearch chemical45▸
Mitochondrial peptide studied for neuroprotection and longevity.
View in the Peptide Database — research, dosing & verified sources →40KPVImmuneResearch chemical44▸
Small anti-inflammatory peptide for gut and skin inflammation.
View in the Peptide Database — research, dosing & verified sources →41LarazotideImmuneResearch chemical43▸
Gut tight-junction regulator studied for leaky gut and celiac disease.
View in the Peptide Database — research, dosing & verified sources →42MatrixylCosmeticCosmetic / OTC42▸
Collagen-boosting peptide in many premium anti-aging skincare products.
View in the Peptide Database — research, dosing & verified sources →43LL-37ImmuneResearch chemical41▸
Antimicrobial peptide studied for infection, biofilms, and wound healing.
View in the Peptide Database — research, dosing & verified sources →44FOXO4-DRILongevityExperimental40▸
Experimental senolytic that clears aged 'zombie' cells.
View in the Peptide Database — research, dosing & verified sources →45SS-31CardiovascularResearch chemical39▸
Mitochondria-targeting peptide protecting heart, muscle, and kidney energy.
View in the Peptide Database — research, dosing & verified sources →46DihexaNootropicResearch chemical38▸
Powerful nootropic peptide studied for memory and new synapse formation.
View in the Peptide Database — research, dosing & verified sources →47ThymalinImmuneResearch chemical37▸
Thymus peptide bioregulator studied for immune restoration in aging.
View in the Peptide Database — research, dosing & verified sources →48VIPImmuneResearch chemical36▸
Signaling peptide used (often intranasally) for chronic inflammation and CIRS.
View in the Peptide Database — research, dosing & verified sources →49PinealonLongevityResearch chemical35▸
Brain-targeting peptide bioregulator studied for neuroprotection.
View in the Peptide Database — research, dosing & verified sources →50SNAP-8CosmeticCosmetic / OTC34▸
Topical peptide marketed as a needle-free alternative to Botox.
View in the Peptide Database — research, dosing & verified sources →Looking for a verified source?
Every peptide above links to its full research page and vetted suppliers. Browse the full Peptide Database, or list your brand.
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