Kisspeptin-10
Also known as: Kp-10, Metastin 45-54, KISS1 peptide
Emerging neuroendocrine peptide — regulates reproductive hormones with promising fertility and libido applications.
Molecular structure image coming soon
Research use only. Not FDA-approved. Clinical trials are ongoing. Use under endocrinology supervision.
Overview
Kisspeptin is a neuropeptide produced in the hypothalamus that serves as the primary regulator of the reproductive axis (HPG axis). Kisspeptin-10 is the shortest active fragment. It stimulates gonadotropin-releasing hormone (GnRH) release, leading to downstream increases in LH, FSH, testosterone, and estrogen. Used in clinical research for fertility treatment, hypogonadism, and sexual function.
Mechanism of Action
Kisspeptin binds KISS1 receptors on GnRH neurons in the hypothalamus, causing robust pulsatile GnRH release. This stimulates LH and FSH from the pituitary, which drives gonadal hormone production. The pathway is essential for puberty onset and maintenance of reproductive function.
Use Cases
- ✓Hypogonadotropic hypogonadism
- ✓Male fertility and testosterone optimization
- ✓Female fertility treatment
- ✓Libido enhancement
- ✓Post-TRT/steroid recovery (HPTA restoration)
Research Summary
Clinical trials at multiple academic medical centers have demonstrated kisspeptin's ability to stimulate LH and testosterone in hypogonadal males and trigger ovulation in females with hypothalamic amenorrhea. Published Phase I/II studies show excellent safety and tolerability.
Typical Dosing
Research protocols vary: 0.25–3 nmol/kg IV in studies. Subcutaneous doses in practice range 2–10 mcg/kg.
Administration
Research Chemical
Research use only. Not FDA-approved. Clinical trials are ongoing. Use under endocrinology supervision.
