Larazotide
Also known as: Larazotide acetate, AT-1001
Tight-junction regulator studied for leaky gut and celiac disease.
Immune & Anti-Inflammatory
Larazotide
Research use only; not approved. Late-stage trial did not meet its primary endpoint.
Overview
Larazotide acetate is a synthetic peptide that helps regulate the tight junctions between intestinal cells. It is the most clinically advanced candidate for celiac disease as an adjunct to a gluten-free diet, and is discussed widely for intestinal permeability (leaky gut).
Larazotide acetate is a synthetic peptide that acts on the tight junctions between the cells lining your intestine — the gates that decide what passes from the gut into the bloodstream. It works as a zonulin antagonist, promoting the assembly and tightening of those junctions and reducing the leak of antigens across the gut barrier. In plain terms, it is aimed directly at intestinal permeability, popularly known as leaky gut.
It is the most clinically advanced candidate ever developed for celiac disease as an add-on to a gluten-free diet. Notably, its pivotal Phase III trial did not meet its primary endpoint, even though earlier studies had suggested symptom benefit — an important, honest caveat. Despite that, it remains widely used and discussed in the gut-health and functional-medicine communities.
Mechanism of Action
Acts as a zonulin antagonist, promoting the assembly of intestinal tight junctions and reducing the paracellular leak of antigens across the gut barrier.
Use Cases
- ✓Celiac disease (adjunct, investigational)
- ✓Intestinal permeability / leaky gut
- ✓Gut barrier support
Research Summary
Reached Phase III for celiac disease; the pivotal trial did not meet its primary endpoint, though earlier data suggested symptom benefit. Widely used in the research-peptide market for gut health.
Explain It Like I'm 5 Years Old
The wall of your gut has tiny doors that are supposed to stay mostly shut, only letting the right things through. Sometimes those doors get stuck open and stuff leaks into your body that should not. Larazotide helps pull those little doors closed again so your gut wall works the way it is meant to.
How the Gym Bros Are Using It
The leaky-gut peptide. Popular with the gut-health crowd and anyone whose hard training and big eating has left their digestion a mess. It is taken orally before meals to help tighten the gut barrier. Be straight about the evidence: its big celiac trial missed its main goal, so it is more promising-and-popular than proven. Often stacked with BPC-157 and KPV in gut-repair protocols.
Verified Sources for Larazotide
OMNI Peptides
Las Vegas, NV
UPGUYS Health
Etobicoke, ON
Boss Peptides
Calgary, AB
XPeptides
Ottawa, ON
Great Northern Peptides
Edmonton, AB
Anglo Peptide Canada
Toronto, ON
Pharma Lab Global Canada
Montreal, QC
UPGUYS
Toronto, ON
Titan Peptide Lab
Online, US
Barcelona Peptide Supply
Barcelona, Catalonia
London Peptide Co.
London, England
Cape Town Peptide Clinic
Cape Town, Western Cape