KPV
Also known as: Lysine-Proline-Valine, alpha-MSH 11-13
Small anti-inflammatory tripeptide studied for gut and skin inflammation.
Immune & Anti-Inflammatory
KPV
Research use only. Limited human data; not FDA-approved.
Overview
KPV is a tripeptide fragment of alpha-MSH with potent anti-inflammatory activity but without the pigmentation effects of the parent hormone. It is studied for inflammatory bowel conditions and skin inflammation.
KPV is a tiny tripeptide — just lysine, proline, and valine — clipped from the tail end of the alpha-MSH hormone. Remarkably, this small fragment keeps the potent anti-inflammatory activity of the parent hormone while dropping the pigmentation effects entirely. It gets inside cells and dampens pro-inflammatory signaling (notably the NF-kB pathway), lowering inflammatory cytokines, and it also shows some antimicrobial activity.
Because of that clean anti-inflammatory action, KPV is studied for inflammatory bowel conditions and for skin inflammation, and it can be delivered orally, topically, or by injection. Preclinical results are encouraging, particularly for calming gut and skin inflammation, though human clinical data remains limited.
Mechanism of Action
Enters cells and reduces pro-inflammatory signaling (NF-kB pathway), lowering inflammatory cytokines. It also shows antimicrobial activity.
Use Cases
- ✓Inflammatory bowel conditions
- ✓Skin inflammation and wound healing
- ✓General anti-inflammatory support
Research Summary
Preclinical studies show KPV reduces intestinal and skin inflammation. Oral and topical delivery are being explored. Human clinical data is limited.
Explain It Like I'm 5 Years Old
KPV is a very small piece of a bigger hormone, but it kept the part that calms down inflammation — like keeping just the fire extinguisher and leaving the rest behind. When part of your gut or skin is red, irritated, and inflamed, KPV helps quiet that down. It is small enough that it can even work as a cream or a capsule, not just a shot.
How the Gym Bros Are Using It
The gut-and-skin calmer. Lifters dealing with gut irritation (often from years of NSAIDs, hard dieting, or high-volume eating) or with inflammatory skin issues use KPV to take the edge off. It is flexible — oral, topical, or injectable — usually a few hundred micrograms a day. Frequently paired with BPC-157 for a gut-healing combo. Not a mass-builder; a recovery and inflammation tool.
Typical Dosing
Research protocols: 200–500 mcg per day, oral or subcutaneous. Not a medical recommendation.
Administration
Research Chemical
Research use only. Limited human data; not FDA-approved.
Related Peptides
Verified Sources for KPV
OMNI Peptides
Las Vegas, NV
UPGUYS Health
Etobicoke, ON
Boss Peptides
Calgary, AB
XPeptides
Ottawa, ON
Great Northern Peptides
Edmonton, AB
Anglo Peptide Canada
Toronto, ON
Pharma Lab Global Canada
Montreal, QC
UPGUYS
Toronto, ON
Titan Peptide Lab
Online, US
Barcelona Peptide Supply
Barcelona, Catalonia
London Peptide Co.
London, England
Cape Town Peptide Clinic
Cape Town, Western Cape