Semax
Also known as: ACTH 4-7 analog, Cognitive enhancer peptide, Neuropeptide Semax
BDNF-boosting cognitive enhancer — improves memory, focus, and neuroprotection.
Molecular structure image coming soon
Research use only in the US. Approved in Russia. May cause transient anxiety at higher doses.
Overview
Semax is a synthetic heptapeptide based on the ACTH 4-10 fragment, developed and approved in Russia for neurological conditions including stroke, cognitive impairment, and optic nerve disease. It is a potent stimulator of BDNF and NGF (nerve growth factor), making it one of the most studied neuroprotective and cognitive-enhancing peptides available.
Mechanism of Action
Semax increases BDNF and NGF synthesis in the brain, promoting neuronal growth, survival, and synaptic plasticity. It also modulates dopaminergic and serotonergic systems, stimulates melanocortin receptors, and exerts anti-inflammatory effects in neural tissue.
Use Cases
- ✓Cognitive enhancement and memory
- ✓Focus and attention (ADHD support)
- ✓Neuroprotection after stroke or TBI
- ✓Depression and mood support
- ✓Optic nerve conditions
- ✓Neurodegenerative disease support
Research Summary
Approved in Russia for ischemic stroke, TBI, optic nerve disease, and cognitive decline. Multiple RCTs demonstrate significant cognitive improvements and neuroprotection. One of the most prescribed neuropeptide treatments in Russian clinical medicine for over 20 years.
