GHK-Cu
Also known as: Copper Peptide, Glycyl-L-histidyl-L-lysine copper, Regenacol
The master wound healing and anti-aging copper peptide — resets over 4,000 genes to a younger state.
Molecular structure image coming soon
Topical formulations are OTC cosmetic products. Injectable GHK-Cu is sold as a research chemical. Consult a provider for injectable protocols.
Overview
GHK-Cu is a naturally occurring copper-binding tripeptide that declines significantly with age (peak in young adulthood, declining ~60% by age 60). Discovered in 1973, it has demonstrated remarkable ability to activate genes associated with tissue repair, collagen synthesis, stem cell activation, antioxidant defense, and anti-aging. It affects expression of over 4,000 genes.
Mechanism of Action
GHK-Cu activates tissue remodeling proteins (MMPs and TIMPs), promotes collagen and glycosaminoglycan synthesis, activates stem cell populations, stimulates nerve outgrowth, exerts anti-inflammatory effects via TNF-alpha suppression, and activates the proteasome for cellular protein cleanup.
Use Cases
- ✓Skin anti-aging (collagen, elastin, wound healing)
- ✓Hair regrowth and follicle stimulation
- ✓Wound healing acceleration
- ✓Systemic anti-aging protocols
- ✓Neurodegenerative conditions (BDNF upregulation)
- ✓Lung tissue repair
Research Summary
Over 50 years of research. Human studies demonstrate significant skin improvements in wrinkle depth, skin tightening, and collagen density. Gene expression analyses show reversal of over 4,000 age-related gene changes. Strong wound healing evidence from dermatological studies. Hair regrowth comparable to minoxidil in some studies.
Typical Dosing
Topical: 0.1–2% cream/serum formulation. Systemic: 2–3 mg subcutaneous daily. Injectable protocols typically 2 mg/day for 4–6 week cycles.
Administration
OTC / Cosmetic
Topical formulations are OTC cosmetic products. Injectable GHK-Cu is sold as a research chemical. Consult a provider for injectable protocols.
